Here’s what you need to know:White flags representing Oklahomans who died of Covid-19 served as a memorial in a front yard in Yukon, Okla., on Saturday.Credit…Nick Oxford for The New York Times

Governments and public health organizations around the world responded slowly and ineffectually to the Covid-19 outbreak, according to an interim report by a World Health Organization panel that laid bare a yearlong cascade of failures.

The report, an early blueprint for accountability, questions the faulty assumptions, ineffective planning and sluggish responses that helped fuel a pandemic that has killed more than 2 million people and infected more than 95 million.

“We have failed in our collective capacity to come together in solidarity to create a protective web of human security,” the Independent Panel for Pandemic Preparedness and Response wrote.

Many of the failings, such as the inability of governments to obtain protective equipment, have long been painfully clear. But the report is stark in its assessment that, time and again, those who were responsible for protecting and leading too often failed to do either.

The panel, led by Helen Clark, the former prime minister of New Zealand, and Ellen Johnson Sirleaf, the former president of Liberia, is still conducting its investigation. But an interim report, laying out the scope of its inquiry, made clear that the world needs to rethink its approach to outbreaks. The panel called the pandemic alert system “slow, cumbersome and indecisive.”

Investigators said they did not understand why a World Health Organization’s committee waited until Jan. 30 to declare an international health emergency. But even when the world health body did send up clear warning signals, the report noted, “In far too many countries, this signal was ignored.”

The report also faulted public health leaders for responding so slowly to early evidence that people without symptoms could spread the new coronavirus. Instead, leading health agencies, including the World Health Organization, provided contradictory and sometimes misleading advice, a New York Times investigation previously found.

The report was scheduled to be released Tuesday. Agence France-Presse reported details of the report on Monday evening. A copy was obtained by The Times.

United States ›
United StatesOn Jan. 17
14-day change

New cases
169,641
+3%

New deaths
1,730
+26%

World ›
WorldOn Jan. 17
14-day change

New cases
549,598
+10%

New deaths
8,933
+23%

Where cases per capita are
highest

People waiting in line at a coronavirus testing site in Los Angeles this month.Credit…Alex Welsh for The New York Times

As the total number of U.S. coronavirus cases surpassed 24 million on Monday, Los Angeles County, one of the hardest-hit areas, may face even more dire weeks ahead. Deaths in the county have continued to climb as the national death toll nears 400,000.

Hospitals have run out of room in intensive care units, though new cases and hospitalizations appear to be leveling off in recent days. The county records a coronavirus-related death roughly every seven minutes, and last week was its highest recorded ever for Covid-19 fatalities.

On Saturday alone, 253 people died of Covid-19, and with variants of the virus that could be more contagious now circulating in California, those numbers may rise.

It took nearly 10 months for the county, America’s most populous, to hit 400,000 cases, but little more than a month to add another 400,000, from Nov. 30 to Jan. 2, according to a New York Times database. On Saturday, the county became the nation’s first to surpass one million recorded coronavirus infections, a number only four states other than California have exceeded: Illinois, New York, Florida and Texas. (California on Sunday became the first state to have recorded more than three million cases.)

And the true scale of infections may be much higher than reported: One in three Los Angeles residents is believed to have been infected with the virus since the beginning of the pandemic, according to the Los Angeles Department of Health. To help quell the spread, the county’s public schools have asked health authorities for permission to begin providing Covid-19 vaccinations.

The virus is surging across California, where daily deaths are averaging 528, an increase of over 15 percent from a week ago. Much of the state, including the southern region, remains under a stay-at-home order.

The state is among many dealing with the arrival of a more contagious viral variant, first discovered in Britain; the first confirmed case in Los Angeles was reported on Saturday. It is believed to be potentially 50 percent more transmissible than the initial version of the virus.

Officials said they thought the variant, which has caused infections to soar in London and southeast England, has been spreading through Los Angeles for some time. While more contagious, the variant does not appear to cause more severe illness.

On Sunday night, the California Department of Public Health reported another variant that had grown more common across the state since December. Known as L452R, it was first detected in Denmark in March and appeared in California in May. In December, researchers at the University of California, San Francisco, sequenced genomes of coronavirus gathered around the state and found that the variant was present in just 3.8 percent of their samples. By January, it had jumped to 25.2 percent.

Charles Chiu, who led the sequencing, cautioned that he and his colleagues worked with a small sample size, so they have not yet proven that this variant is more contagious. “But there are worrisome signs that this variant may be highly transmissible,” he said.

Dr. Chiu and his colleagues are now looking more carefully for this variant across the state and are trying to understand how its mutations have altered it. They want to see if the variant can escape from monoclonal antibodies and perhaps even make vaccines less effective. “These are critical studies that need to be done,” Dr. Chiu said.

After weeks under a stay-at-home order, the county’s positivity rate is starting to taper. Dr. George Rutherford, an epidemiologist at the University of California, San Francisco, said the state and Los Angeles seemed to be “in the process of sort of gradually turning a corner here.”

He cautioned against panicking about the more transmissible variant, noting the same cautious behavior will help keep it at bay: stay home, wear a mask, physically distance.

Community Hospital of Huntington Park in Los Angeles earlier this month.Credit…Philip Cheung for The New York Times

For nearly the entire pandemic, political polarization and a rejection of science have stymied the United States’ ability to control the coronavirus.

That has been clearest and most damaging at the federal level, where President Trump claimed that the virus would “disappear,” clashed with his top scientists and abdicated responsibility for a pandemic that required a national effort to defeat it, handing key decisions to states under the assumption that they would take on the fight and get the country back to business.

But governors and local officials who were left in charge of the crisis squandered the little momentum the country had as they sidelined health experts, ignored warnings from their own advisers and, in some cases, stocked their advisory committees with more business representatives than doctors.

Nearly one year since the first known coronavirus case in the United States was announced north of Seattle on Jan. 21, 2020, the country is hurtling toward 400,000 total deaths, and cases, hospitalizations and deaths have reached record highs.

The situation has turned dire just as the Trump administration, in its final days, begins to see the fruits of perhaps its biggest coronavirus success, the Operation Warp Speed vaccine program. But already, a lack of federal coordination in distributing doses has emerged as a troubling roadblock.

The incoming president, Joseph R. Biden Jr., has said he will reassert a federal strategy to bring the virus under control, including a call for everyone to wear masks over the next 100 days and a coordinated plan to widen the delivery of vaccines.

“We will manage the hell out of this operation,” Mr. Biden said on Friday. “Our administration will lead with science and scientists.”

The strategy signals a shift from the past year, during which the Trump administration largely delegated responsibility for controlling the virus and reopening the economy to 50 governors, fracturing the nation’s response. Interviews by The Times with more than 100 health, political and community leaders around the country and a review of emails and other state government records offer a fuller picture of all that went wrong.

VideoAhmed Nafei via FacebookCreditCredit…Ahmed Nafei via Facebook

A nurse’s cry pierced the night from the balcony of an Egyptian hospital. She was screaming that the patients in the Covid-19 intensive care unit were gasping for air.

Ahmed Nafei, who was standing outside, brushed past a security guard, dashed in and saw that his 62-year-old aunt was dead.

Furious, he whipped out his phone and began filming. It appeared that the hospital had run out of oxygen. Monitors were beeping. A nurse was distressed and cowering in a corner as her colleagues tried to resuscitate a man using a manual ventilator.

At least four patients died.

Mr. Nafei’s 47-second video this month of the chaos at El Husseineya Central Hospital, about two and a half hours northeast of Cairo, spread rapidly on social media.

As outrage grew, the government denied that the hospital had run out of oxygen.

An official statement issued the following day concluded that the four who died had suffered from “complications” and denied that the deaths had “any connection” to an oxygen shortage. Security officers interrogated Mr. Nafei, and officials blamed him for violating rules barring visits and filming inside hospitals.

A New York Times investigation, however, found witnesses, including medical staff and relatives of patients, who said in interviews that the oxygen had fallen to precipitously low levels. At least three patients, they said, and possibly a fourth, had died of oxygen deprivation. A close analysis of the video by doctors in Egypt and the United States confirmed that the chaotic scene indicated an interruption in the oxygen supply.

The oxygen shortage was the result of a cascade of problems at the hospital, The Times’s investigation found. By the time patients were suffocating, a relief delivery of oxygen was already hours late and a backup oxygen system had failed.

“We’re not going to bury our heads in the sand and pretend everything is OK,” a doctor at the hospital said, speaking on condition of anonymity because he feared arrest. “The whole world can admit there’s a problem, but not us.”

The government’s rush to deny the episode is only the latest example of the lack of transparency in its response to the pandemic, which has led to cynicism and distrust of its public assurances.

Nurses, doctors and health professionals receiving Sinovac’s CoronaVac vaccine in São Paulo, Brazil, on Monday.Credit…Victor Moriyama for The New York Times

Brazil approved two coronavirus vaccines for emergency use while rejecting an application for a third as South America’s most populous nation began a vaccination program that had been mired in chaos.

On Sunday, Brazil’s health regulator, Anvisa, authorized the vaccine from Sinovac, a private Chinese company that developed it in partnership with the Butantan Institute in São Paulo. It approved the vaccine produced by the University of Oxford in partnership with AstraZeneca, the British-Swedish pharmaceutical company.

A day earlier, regulators rejected an application for the Sputnik V vaccine developed by Russia, saying more documentation was needed.

Mônica Calazans, 54, a nurse in the state of São Paulo, was given the first shot of Sinovac’s CoronaVac vaccine on Sunday. Federal officials said vaccinations were expected to begin in all Brazilian states on Wednesday.

The first vaccination was attended by João Doria, the governor of São Paulo, who has feuded with Jair Bolsonaro, the president of Brazil, over the approval and rollout of vaccines. Mr. Bolsonaro had dismissed the seriousness of the pandemic and cast doubt on the Sinovac vaccine, while Mr. Doria negotiated directly with the Chinese to acquire doses. Brazil has had one of the worst outbreaks in the world, with the third-highest number of cases after the United States and India and the second-highest number of deaths after the United States, according to a New York Times database.

New questions about the efficacy of the Chinese vaccine emerged last week after officials at the Butantan Institute downgraded its efficacy to just over 50 percent, far below the 78 percent level announced earlier but still above the benchmark that the World Health Organization has said would make a vaccine effective for general use. That announcement signaled potential obstacles for China’s vaccine diplomacy as well as the epidemic control measures of countries that plan to use the Sinovac vaccine. So far at least 10 countries have ordered CoronaVac, seeking a total of 380 million doses.

Manuela Andreoni contributed reporting.

Members of the National Guard last week outside the U.S. Capitol, where up to 25,000 troops are expected for the inauguration on Wednesday.Credit…Jason Andrew for The New York Times

In recent days, tens of thousands of National Guard troops have flooded into Washington from across the country to protect lawmakers and ensure a smooth transition to the next administration.

The soldiers — several times more troops than are deployed to Iraq, Afghanistan, Somalia and Syria — may also be dealing with another risk: the coronavirus. At least 43 troops deployed to Washington contracted the virus, The Military Times reported, though none while on duty in the city, according to Air Force Capt. Tinashe T. Machona.

A spokesman for the D.C. National Guard, Maj. Matt Murphy, said that while Guard members with symptoms were directed to get tested and seek medical care, the size of the operation meant that testing all members was not feasible. Members underwent temperature checks and filled out questionnaires about their symptoms and exposure, he said.

“All 50 states, three territories and the District of Columbia are involved in this operation,” Major Murphy said. “To track down all 54 surgeon generals to see if they’re able to release numbers regarding their troops at this time would overwhelm us.”

Linsey Marr, a professor of civil and environmental engineering at Virginia Tech, said that while it was “very important for them to be there,” Guard members “should be doing everything reasonably possible” to prevent the spread, including wearing masks, getting tested and exercising extra caution in higher-risk settings like being in vehicles together, resting in the Capitol (as many have been pictured doing) and eating indoors.

“It’s almost certain that some of them are carrying the virus” with such a large crowd, Dr. Marr said.

Delaware National Guard members, from right, Charles, Reynolds and Valley, who were permitted to give only their last names, on the floor of the Capitol last week.Credit…T.J. Kirkpatrick for The New York Times

The troops are frequently photographed in masks, standing at a distance. But many had to sleep huddled in crowded spaces in the Capitol, making room for lawmakers to continue business.

Dr. Ashish Jha, the dean of Brown University’s School of Public Health, said that systematic testing should be a priority for a group of that size, including for asymptomatic cases. “These folks are there to protect our political leaders, but we should not be putting them in harm’s way unnecessarily by not doing what we can to protect them from the virus,” he said.

The troops are mostly processed through the D.C. Armory, where they fill out a medical questionnaire, receive credentials and find out about their assignments and other logistics.

Earlier this summer, when the National Guard deployed troops to Washington for Black Lives Matter protests, a few tested positive, McClatchy reported at the time. The infected Guard members stayed in the city and quarantined while others went back to their home states.

The City of Los Angeles opened a mass vaccination site at Dodger Stadium last week.Credit…Pool photo by Irfan Khan

Public schools in Los Angeles, which are already administering a huge coronavirus testing and tracing program for students, teachers and families in the nation’s second-largest district, have asked the state and county health authorities for permission to begin providing Covid-19 vaccinations, the superintendent said on Monday.

Austin Beutner, the superintendent, said the Los Angeles Unified School District was “uniquely situated — and uniquely qualified — to help in the vaccination effort,” with a dozen licensed clinics, 42 testing locations, more than 450 registered school nurses and partnerships with insurers that would allow them to begin administering inoculations immediately.

Though school districts in New York, Kansas City and the California cities of Riverside, Ventura and Long Beach have committed to vaccinate or have begun vaccinating school employees, schools have yet to be broadly deployed for general distribution of coronavirus vaccines.

But Los Angeles Unified, which has more than 1,400 K-through-12 schools and serves nearly 700,000 mostly low-income students across 710 square miles of Southern California, has throughout the pandemic operated not only as a school system, but as a large-scale social service and relief organization, distributing nearly 100 million free meals, as well as pandemic supplies and virus tests, to students and employees and to their families. The district is also in a county with soaring rates of coronavirus infection: One-third of Los Angeles County residents are now estimated to have contracted the virus.

“We’re raising our hand and saying, ‘Put me in, coach — we can help,’” Mr. Beutner said.

Last week, counties and cities throughout the state began opening mass inoculation sites by appointment to accommodate patients unable to obtain vaccines from their pharmacists or doctors. The City of Los Angeles opened a site at Dodger Stadium, and Los Angeles County has said it will open five more such sites on Tuesday.

It is unclear whether the public health authorities will take the school district up on its offer. But Mr. Beutner called the notion of school-based community vaccination centers “just common sense.”

Schools have been integral to vaccine distributions in the past, operating as sites in the 1950s for the inoculation of millions of schoolchildren against polio, for instance, and in 2009 for the distribution of millions of doses of vaccines for the H1N1 swine flu virus.

Grace Cathedral International Church, led by Bishop Robert Harris, hosted a pop-up vaccine clinic Monday to help the predominately Black community in Uniondale, N.Y., combat the coronavirus.Credit…Laylah Amatullah Barrayn for The New York Times

Shortly after Bishop Robert Harris sent out an email last week telling parishioners that his church in Uniondale, N.Y., would be a pop-up site for Covid-19 vaccinations on Martin Luther King Jr. Day, the phone in the office at Grace Cathedral International Church started ringing nonstop.

Members of several other churches in Uniondale had received the emails, and word spread quickly beyond the immediate community, triggering even more calls to register for shots.

“One woman called me crying, saying, ‘Thank you so much,’ that they’ve just been waiting so long for this,” said Shareese Harris, the bishop’s granddaughter, who was answering the phones at the church office on Friday.

“She said she hasn’t been able to see her newborn grandson because she didn’t want to be around him and risk his health, and she just broke down crying. She said it was a prayer answered.”

The vaccination drive is an element of a health equity outreach project sponsored by Northwell Health, as part of a statewide effort led by Gov. Andrew Cuomo that aims to take critical Covid-19 health care services into Black and Hispanic communities that were hard-hit by the epidemic. The clinical sites at churches in diverse neighborhoods allow residents without transportation easy access to care at a trusted institution.

Many Black and Hispanic churches participated in similar initiatives last spring, when they became temporary sites offering tests for Covid-19 and for antibodies.

People of color, including Black, Hispanic, Native American and, to a lesser extent, Asian-Americans, have been disproportionately impacted by the pandemic.

Another Long Island church, the Prayer Tabernacle Church of God In Christ in Amityville, also hosted a one-day pop-up vaccination clinic on Monday. The two sites hoped to dispense 250 vaccine doses each, and Northwell officials said they hoped to continue the program as long as supplies last.

Public opinion surveys have found that Black Americans are more likely than others to be concerned about the safety of the Covid-19 vaccines, with a recent Kaiser Family Foundation survey reporting that while about one-quarter of Americans are hesitant about the new vaccines, 35 percent of Black Americans said they definitely or probably would not get the vaccine because of concerns about its safety and novelty.

But Bishop Harris said the community has lost so many people to Covid-19 that the vaccine will be welcomed.

“We don’t have a history about the long-term impact of the vaccine, but we’ve got 4,000 people dying a day,” said Mr. Harris, 78, who has been vaccinated. “I’d rather take a gamble with the vaccine than not. You become fearful when it comes so close.”

global roundup

Attending to a patient at the Covid-19 emergency room of Santa Maria hospital in Lisbon last week. Portugal has one of Europe’s smallest intensive-care capacities.Credit…Patricia De Melo Moreira/Agence France-Presse — Getty Images

Portugal’s hospitals are on the brink of becoming overwhelmed with coronavirus cases, with fears the country’s hospital system could buckle in the face of steadily rising infections. The country has registered more than 10,000 new cases of Covid-19 daily for the last five days.

Portugal has one of smallest intensive care unit capacities of any country in Europe, with just 672 beds available, and by Sunday, 647 intensive care patients were being treated for the coronavirus, according to the health ministry.

After visiting a hospital on Sunday, President Marcelo Rebelo de Sousa of Portugal told journalists that there was now pressure on health care structures that were greater than the first peak of the outbreak in March. The rate of infections, he added, could rise significantly in the coming weeks and necessitate “a much longer lockdown.”

Portugal began a month of nationwide restrictions on Friday, with measures similar to those the country enforced last spring, including the closure of nonessential stores and an order for citizens to stay at home.

Marta Temido, Portugal’s health minister, said the country was “very close to the limit” after visiting a hospital in Almada on Sunday and called on citizens to follow the latest lockdown rules in order to help reduce the “very high” pressure on hospitals.

“Everybody needs to make sacrifices,” she said.

Here’s what to know from elsewhere in the world:

European leaders are set to debate a proposal this week for coronavirus “passports” that would let vaccinated people travel freely within the bloc. Prime Minister Kyriakos Mitsotakis of Greece, where travel restrictions have hit the tourism industry hard, said in a letter to the president of the bloc’s executive arm that it was “urgent” for member states “adopt a common understanding” on vaccination certificates, according to Reuters. The issue is expected to be discussed during a video conference on E.U. coronavirus coordination on Friday.

Australia’s health secretary said the country was unlikely to fully reopen its borders in 2021, despite vaccination efforts and pressures from the tourism industry. Speaking to ABC News on Monday morning, the minister, Brendan Murphy, said that restarting international travel remained “a big question.”

“I think that we’ll go most of this year with still substantial border restrictions,” he said.

Germany’s health ministry has announced plans to systematically sequence coronavirus samples in order to detect and track variants of the virus that have the potential to spread more swiftly. “We want to be able to understand even better where known mutations are spreading and whether new mutations are occurring,” Jens Spahn, the health minister, said on Monday. The goal is to sequence at least 5 percent of new infections. Mr. Spahn said that while the variant that spread rapidly in England had been found in Germany, it was mostly linked to patients who had traveled from Britain.

In Japan, the health ministry reported three new cases on Monday of the variant that spread in Britain, the first to be discovered among residents with no travel history. Japan has reported a total of 45 cases of three different coronavirus variants, all but these latest three among people who had recently traveled or were close contacts of travelers from Britain, South Africa or Brazil. The three new cases were all confirmed in Shizuoka Prefecture, south of Tokyo and the home of Mt. Fuji, Japan’s highest peak.

Vaccinations at a government hospital in Ahmedabad, India, on Saturday.Credit…Ajit Solanki/Associated Press

India’s coronavirus vaccine rollout, one of the largest in the world, has been hobbled by technical glitches in a mobile phone application, leaving the country far short of its vaccination goals in the first few days of the campaign.

State officials complained of problems with a digital platform called the Covid Vaccine Intelligence Network, or CoWIN, which is used by both vaccine providers and recipients to monitor the campaign’s progress. It is mandatory for vaccine recipients to register on the app in order to be inoculated.

Dr. Ajoy Kumar Chakraborty, director of health services in the state of West Bengal, said Monday that the software had become overwhelmed and didn’t work at many vaccination sites, and that vaccinations were curtailed as a result.

In the first phase of the campaign, which began on Saturday, government officials plan to vaccinate 30 million health and frontline workers. On the first day, about 300,000 health care workers were set to be inoculated; the actual number was about 207,000. On Sunday, the number dropped to 17,072.

Dr. Manohar Agnani, a senior official in the federal Ministry of Health and Family Welfare, said on Sunday that feedback was being collected from states to “identify bottlenecks and plan corrective action.”

India has approved two vaccines for emergency use. One is the vaccine developed by AstraZeneca and Oxford University, which is manufactured by the Serum Institute of India and is known in the country as Covishield. The other is Covaxin, which was developed by India’s National Institute of Virology with Bharat Biotech, a local pharmaceutical company.

The government of India, which has a population of 1.3 billion people, has so far purchased 11 million doses of Covishield and 5.5 million doses of Covaxin, both of which require two doses per person. Unlike the Oxford-AstraZeneca vaccine, no Phase 3 clinical trial data has been released showing that Covaxin is safe and effective. Officials have said that vaccine recipients will not get to choose between the two.

Doubts about transparency are only one of the obstacles officials face in trying to end one of the largest outbreaks in the world. India has the second-highest number of cases after the United States, and the third-highest number of deaths after the United States and Brazil, according to a New York Times database.

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‘Wall of Inequality,’ W.H.O. Warns of Vaccine DistributionThe head of the World Health Organization says that the promise of equitable access to the vaccines “is at serious risk.”

We now face the real danger that even as vaccines bring hope to some, they become another brick in the wall of inequality. It’s right that all governments want to prioritize vaccinating their own health workers and older people first. But it’s not right that younger, healthier adults in rich countries are vaccinated before health workers and older people in poorer countries. Thirty-nine million doses of vaccine have now been administered in at least 49 higher income countries. Just 25 doses have been given in one lowest income country. Not 25 million, not 25 thousand, just 25. I need to be blunt. The world is on the brink of a catastrophic moral failure. And the price of this failure will be paid with lives and livelihoods in the world’s poorest countries.

The head of the World Health Organization says that the promise of equitable access to the vaccines “is at serious risk.”CreditCredit…Tim Gruber for The New York Times

The head of the World Health Organization has warned that the world is on the brink of a “moral failure” in ensuring coronavirus vaccines are distributed among the world’s poorest populations, and that the promise of equitable access to the vaccines “is at serious risk.”

Dr. Tedros Adhanom Ghebreyesus, the director general of the World Health Organization, speaking at the opening session of a meeting of its executive board, said the world had the opportunity to “write a different story” than those of past pandemics in which rich countries benefited from widespread access to vaccines while the world’s poor were neglected.

“We now face the real danger that even as vaccines bring hope to some, they become another brick in the wall of inequality between the world’s haves and have-nots,” he said.

While the “stunning scientific achievement” of developing a vaccine in under a year has become “a much-needed source of hope,” Dr. Tedros warned that the world must do more to ensure the equitable distribution of the finite supply of approved vaccines to poorer nations.

In recent months, rich nations like the United States and Britain have cut deals with drug manufacturers and secured enough vaccine doses to ensure their citizens could be vaccinated, often multiple times over, and programs have already begun in most.

“Its right that all governments want to prioritize vaccinating health workers and older people first,” he said. But it was “not right” for young, healthy people in rich countries to be vaccinated before the more vulnerable.

Many nations have also committed to taking part in a complex vaccine-sharing scheme called Covax, a collaboration between international health organizations and global partners, designed to ensure that the world’s poorest nations can access vaccines. But Dr. Tedros said that in recent weeks, worrisome reports had made him fear wealthier nations would not follow through on their commitments.

“I need to be blunt: The world is on the brink of a catastrophic moral failure, and the price of this failure will be paid with lives and livelihoods in the world’s poorest countries,” he said.

Dr. Tedros noted that even the countries and companies that “speak the language of equitable access” have continued to prioritize bilateral vaccine deals that circumvent the Covax program, drive up prices and see nations “attempting to jump to the front of the queue.”

“This is wrong,” he said.

Members of the Park Police patrolling the Lincoln Memorial last week. Credit…Oliver Contreras for The New York Times

President-elect Joseph R. Biden Jr., who ran on a platform of addressing the pandemic with competence and compassion, will preside over a national memorial honoring the nearly 400,000 people who have died of the coronavirus shortly after arriving in Washington on Tuesday, his inaugural committee said Monday.

Mr. Biden, Vice President-elect Kamala Harris and their families plan to participate in the lighting of 400 lights to illuminate the perimeter of the reflecting pool in front of the Lincoln Memorial in their first stop in the city ahead of Wednesday’s inauguration, the committee said.

Each light is meant to represent approximately 1,000 Americans who will have perished related to the virus at the time of his swearing-in.

Tuesday’s ceremony will kick off “a national moment of unity” at 5:30 p.m. Eastern that will include similar memorials at the Empire State Building, the Space Needle in Seattle and other landmarks across the country, with events also planned for Mr. Biden’s hometowns of Scranton, Penn., and Wilmington, Del.

The inauguration “represents the beginning of a new national journey — one that renews its commitment to honor its fallen and rise toward greater heights in their honor,” the committee’s chief executive, Tony Allen, president of Delaware State University, said in a statement.

Cardinal Wilton Gregory, Archbishop of Washington, will deliver the invocation at the Lincoln Memorial event. Two acclaimed gospel singers, Yolanda Adams and Lori Marie Key, will perform at the commemoration.

In recent days, the committee’s staff has reached out to church and civic leaders around the country to participate in the memorial, with a particular focus on involving Black and Latino communities, which have been disproportionately hit by the pandemic.

On Sunday, Ron Klain, the incoming White House chief of staff, had a dire forecast for the course of the coronavirus outbreak in the new administration’s first weeks, predicting that half a million Americans will have died from the coronavirus by the end of February. The current death toll is nearing 400,000 and on Monday, the United States surpassed 24 million cases of the virus.

“The virus is going to get worse before it gets better,” Mr. Klain said in an appearance on CNN’s “State of the Union.” “People who are contracting the virus today will start to get sick next month, will add to the death toll in late February, even March, so it’s going to take awhile to turn this around.”

On Friday, federal health officials warned of a fast spreading, far more contagious variant of the virus that is projected to become the dominant source of infection in the country by March, potentially fueling another wrenching surge of cases and deaths.

Jonathan Sumption in London in 2010, two years before he joined Britain’s Supreme Court. He retired from the court in 2018, and has become a prominent anti-lockdown voice.Credit…Ben Stansall/Agence France-Presse — Getty Images

A former British Supreme Court justice is drawing condemnation after clashing with a woman with cancer during a televised debate over the country’s lockdown.

Jonathan Sumption, 72, who was a Supreme Court justice for six years before retiring in 2018 and has become one of the country’s most prominent anti-lockdown voices, said during a discussion broadcast on the BBC on Sunday that he did not accept that “all lives were of equal value.”

When he argued that the lives of his children and grandchildren were “worth much more” because of potential years ahead, another panelist pushed back.

“I’m the person who you say their life is not valuable,” said Deborah James, who hosts a podcast on the BBC and has stage four, metastatic bowel cancer.

Lord Sumption responded: “I didn’t say it wasn’t valuable, I said it was less valuable.”

“Who are you to question and put a value to life?” Ms. James then continued. “I believe life is sacred and I don’t think we should make those judgment calls.”

The exchange provoked outrage online, with critics calling the former judge’s position “morally deficient,” “inhumane” and reminiscent of arguments for eugenics.

Lord Sumption said later that his comments had been misinterpreted, telling the British newspaper The Daily Mail: “I object extremely strongly to any suggestion that I was inferring that Miss James’s life was less valuable because she had cancer. I thought she was responding to my earlier comments about older people being protected by a total lockdown which is causing immense harm to the young who are unaffected.

“That harm can be to their mental health or through cooping undergraduates up at university or through the loss of jobs. I was saying this should not be inflicted on the young to protect old people like me.”

“One of the problems is that we were talking across each other,” he said on another television show, “Good Morning Britain,” on Monday, adding that he and Ms. James had had a friendly exchange afterward and he regarded the matter as “closed.”

The point he was trying to make, he said, was that policymakers had to make difficult choices including putting a value on human life. “This is a tool for policymakers,” he said. “It’s not a way of valuing individuals.”

A doctor at the Jeffrey Cheah Biomedical Centre, in Cambridge, Britain analyzing samples of the coronavirus last week to determine how the virus is mutating.Credit…Mary Turner for The New York Times

At the heart of each coronavirus is its genome, a twisted strand of nearly 30,000 “letters” of RNA. These genetic instructions force infected human cells to assemble up to 29 kinds of proteins that help the coronavirus multiply and spread.

As viruses replicate, small copying errors known as mutations naturally arise in their genomes. A lineage of coronaviruses will typically accumulate one or two random mutations each month.

A coronavirus variant first reported in Britain, named Variant of Concern 202012/01 by Public Health England, is part of the B.1.1.7 lineage of coronaviruses, and is believed to be potentially 50 percent more transmissible than the initial version of the virus.

Some mutations have no effect on the coronavirus proteins made by the infected cell. Other mutations, like those in B.1.1.7, might alter a protein’s shape by changing or deleting one of its amino acids, the building blocks that link together to form the protein.

Through the process of natural selection, neutral or slightly beneficial mutations may be passed down from generation to generation, while harmful mutations are more likely to die out.

The B.1.1.7 lineage has now been detected in over 50 countries, including the United States. Britain has responded to the surge of B.1.1.7 with stringent lockdowns, and other countries have tried to prevent its spread with travel restrictions.

Federal health officials warn that it may become the dominant variant in the United States by March. It is no more deadly than other forms of the coronavirus. But because it can cause so many more infections, it may lead to many more deaths.

B.1.1.7 has been detected in at least 14 states, but the United States has no national surveillance program for determining the full extent of its spread.

Anna Limburg, left, and Mary Gaylord,r, with Walgreens, preparing syringes of the Pfizer-BioNTech Covid-19 vaccine at the Hebrew home in The Bronx, New York, last month.Credit…James Estrin/The New York Times

Facing a shortage of coronavirus vaccines in New York, Gov. Andrew M. Cuomo on Monday asked the pharmaceutical giant Pfizer to directly sell doses to New York, so that the state would no longer have to rely solely on the federal government to distribute doses. But it was unclear whether the company would be able to do so.

Speaking at a news conference, Mr. Cuomo noted that Pfizer did not have to follow Moderna’s exact commitments to the Trump administration’s Operation Warp Speed vaccine program, so he wondered whether it might be able to sell doses directly to the state.

But a spokeswoman for Pfizer said Monday that the company would need approval from the federal government to sell directly to state governments. Such a move would seem unlikely within the last 48 hours of President Trump’s tenure; representatives for the federal Department of Health and Human Services and the transition team for President-elect Joseph R. Biden Jr., who will be sworn into office on Wednesday, did not immediately respond to requests for comment.

Under agreements with the Trump administration, Pfizer has committed to selling a total of 200 million doses of its vaccine, developed with BioNTech, to the federal government. The first tranche, of 100 million doses, was committed last summer even before the vaccine was found to be effective. Last month, the company agreed to deliver another 70 million doses by the end of June and an additional 30 million by the end of July.

“Pfizer is a New York company — something I am greatly proud of,” Mr. Cuomo wrote in a letter to Pfizer’s chief executive, Dr. Albert Bourla, adding, “the distribution of any doses obtained directly from Pfizer will follow the rigorous guidance the state has established, while enabling us to fill the dosage gap created this week by the outgoing federal administration.”

Mr. Cuomo said over one million vaccine doses have been administered across the state so far, but said New York urgently needed a solution to its supply issue.



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